<!DOCTYPE html>
<html class="client-nojs vector-feature-language-in-header-enabled vector-feature-language-in-main-page-header-disabled vector-feature-page-tools-pinned-disabled vector-feature-toc-pinned-clientpref-0 vector-toc-not-available vector-feature-main-menu-pinned-disabled vector-feature-limited-width-clientpref-1 vector-feature-limited-width-content-enabled vector-feature-custom-font-size-clientpref-1 vector-feature-appearance-pinned-clientpref-0 skin-theme-clientpref-day vector-sticky-header-enabled" lang="de" dir="ltr"><head>
<meta charset="UTF-8">
<title>Allan Maxam</title>
<meta name="viewport" content="width=device-width, initial-scale=1.0">
<link rel="icon" type="image/png" href="./_res_/favicon.png">
<link rel="canonical" href="https://de.wikipedia.org/wiki/Allan_Maxam"> <link href="./_mw_/ext.cite.styles.css" rel="stylesheet" type="text/css">
<link href="./_mw_/ext.wikimediamessages.styles.css" rel="stylesheet" type="text/css">
<link href="./_mw_/skins.vector.icons.css" rel="stylesheet" type="text/css">
<link href="./_mw_/skins.vector.search.codex.styles.css" rel="stylesheet" type="text/css">
<link href="./_mw_/skins.vector.styles.css" rel="stylesheet" type="text/css">
<meta name="ResourceLoaderDynamicStyles" content="">
<link href="./_mw_/ext.gadget.citeRef.css" rel="stylesheet" type="text/css">
<link href="./_mw_/ext.gadget.defaultPlainlinks.css" rel="stylesheet" type="text/css">
<link href="./_mw_/ext.gadget.dewikiCommonHide.css" rel="stylesheet" type="text/css">
<link href="./_mw_/ext.gadget.dewikiCommonLayout.css" rel="stylesheet" type="text/css">
<link href="./_mw_/ext.gadget.dewikiCommonStyle.css" rel="stylesheet" type="text/css">
<link href="./_mw_/ext.gadget.dewikiDarkmode.css" rel="stylesheet" type="text/css">
<link href="./_mw_/ext.gadget.dewikiResponsive.css" rel="stylesheet" type="text/css">
<link href="./_mw_/ext.gadget.specialSearch.css" rel="stylesheet" type="text/css">
<link rel="stylesheet" type="text/css" href="./_mw_/site.styles.css">
<link rel="stylesheet" type="text/css" href="./_mw_/noscript.css">
<link rel="stylesheet" type="text/css" href="./_res_/footer.css">
<link rel="stylesheet" type="text/css" href="./_res_/vector-2022.css">
</head>
<body class="skin--responsive skin-vector skin-vector-search-vue mediawiki ltr sitedir-ltr mw-hide-empty-elt ns-0 ns-subject page-Allan_Maxam rootpage-Allan_Maxam skin-vector-2022 action-view">
<div class="mw-page-container">
<div class="mw-page-container-inner">
<div class="mw-content-container">
<main id="content" class="mw-body">
<header class="mw-body-header vector-page-titlebar">
<h1 id="firstHeading" class="firstHeading mw-first-heading"><span class="mw-page-title-main">Allan Maxam</span></h1>
</header>
<a id="top"></a>
<div id="bodyContent" class="vector-body ve-init-mw-desktopArticleTarget-targetContainer" aria-labelledby="firstHeading" data-mw-ve-target-container="">
<div id="contentSub">
<div id="mw-content-subtitle"></div>
</div>
<div id="mw-content-text" class="mw-body-content mw-content-ltr" lang="de" dir="ltr"><div class="mw-content-ltr mw-parser-output" lang="de" dir="ltr"><p><b>Allan M. Maxam</b> (* <a href="28._Oktober" title="28. Oktober">28. Oktober</a> <a href="1942" title="1942">1942</a>) ist ein US-amerikanischer Molekularbiologe.
</p><p>Maxam wurde an der <a href="Harvard_University" title="Harvard University">Harvard University</a> bei <a href="Walter_Gilbert" title="Walter Gilbert">Walter Gilbert</a> in Molekularbiologie promoviert und war dort ab 1980 Assistant Professor in Biologie am Dana Farber Cancer Institute. Ende der 1990er Jahre war er am Biolinguistics Institute in <a href="Cambridge_(Massachusetts)" title="Cambridge (Massachusetts)">Cambridge (Massachusetts)</a>.<sup id="cite_ref-1" class="reference"><a href="#cite_note-1"><span class="cite-bracket">[</span>1<span class="cite-bracket">]</span></a></sup>
</p><p>Bekannt ist er für die Erfindung einer <a href="DNA-Sequenzierung#Methode_von_Maxam_und_Gilbert" title="DNA-Sequenzierung">Gensequenzierungsmethode</a> mit <a href="Walter_Gilbert" title="Walter Gilbert">Walter Gilbert</a> (1977), der insbesondere dafür 1980 den Nobelpreis erhielt und die sie zu Pionieren der Gentechnik machten. Sie kombiniert Markierung (radioaktiv oder mit Farbstoffen) von DNA-Strängen, gezieltes Zerschneiden der DNA an bestimmten Basen mit speziellen Reagenzien und <a href="Gelelektrophorese" title="Gelelektrophorese">Gelelektrophorese</a>. In den späteren Gensequenzierungsprojekten wurde meist ein anderes Verfahren verwendet, das 1975 von <a href="Frederick_Sanger" title="Frederick Sanger">Frederick Sanger</a> entwickelt wurde, Enzyme verwendet und eine weitgehende Automatisierung erlaubt.
</p>
<div class="mw-heading mw-heading2"><h2 id="Schriften">Schriften</h2></div>
<ul><li>Walter Gilbert, Allan Maxam: <cite style="font-style:italic">The Nucleotide Sequence of the lac Operator</cite>. In: <cite style="font-style:italic">PNAS</cite>. <span style="white-space:nowrap">Band<span style="display:inline-block;width:.2em"> </span>70</span>, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>12</span>, Dezember 1973, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>3581–3584</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1073/pnas.70.12.3581">10.1073/pnas.70.12.3581</a></span>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:Allan+Maxam&rft.atitle=The+Nucleotide+Sequence+of+the+lac+Operator&rft.au=Walter+Gilbert%2C+Allan+Maxam&rft.date=1973-12&rft.doi=10.1073%2Fpnas.70.12.3581&rft.genre=journal&rft.issue=12&rft.jtitle=PNAS&rft.pages=3581-3584&rft.volume=70" style="display:none"> </span></li>
<li>A. M. Maxam, W. Gilbert: <cite style="font-style:italic">A new method for sequencing DNA</cite>. In: <cite style="font-style:italic"><a href="Proceedings_of_the_National_Academy_of_Sciences" class="mw-redirect" title="Proceedings of the National Academy of Sciences">PNAS</a></cite>. <span style="white-space:nowrap">Band<span style="display:inline-block;width:.2em"> </span>74</span>, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>2</span>, Februar 1977, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>560–564</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1073/pnas.74.2.560">10.1073/pnas.74.2.560</a></span>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:Allan+Maxam&rft.atitle=A+new+method+for+sequencing+DNA&rft.au=A.+M.+Maxam%2C+W.+Gilbert&rft.date=1977-02&rft.doi=10.1073%2Fpnas.74.2.560&rft.genre=journal&rft.issue=2&rft.jtitle=PNAS&rft.pages=560-564&rft.volume=74" style="display:none"> </span></li>
<li>Allan M. Maxam, Richard Tizard, Konstantin G. Skryabin, Walter Gilbert: <cite style="font-style:italic">Promoter region for yeast 5S ribosomal RNA</cite>. In: <cite style="font-style:italic"><a href="Nature" title="Nature">Nature</a></cite>. <span style="white-space:nowrap">Band<span style="display:inline-block;width:.2em"> </span>267</span>, <span style="white-space:nowrap">Nr.<span style="display:inline-block;width:.2em"> </span>5612</span>, 16. Juni 1977, <span style="white-space:nowrap">S.<span style="display:inline-block;width:.2em"> </span>643–645</span>, <a href="Digital_Object_Identifier" title="Digital Object Identifier">doi</a>:<span class="uri-handle" style="white-space:nowrap"><a rel="nofollow" class="external text" href="https://doi.org/10.1038/267643a0">10.1038/267643a0</a></span>.<span class="Z3988" title="ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rfr_id=info:sid/de.wikipedia.org:Allan+Maxam&rft.atitle=Promoter+region+for+yeast+5S+ribosomal+RNA&rft.au=Allan+M.+Maxam%2C+Richard+Tizard%2C+Konstantin+G.+Skryabin%2C+...&rft.date=1977-06-16&rft.doi=10.1038%2F267643a0&rft.genre=journal&rft.issue=5612&rft.jtitle=Nature&rft.pages=643-645&rft.volume=267" style="display:none"> </span></li></ul>
<div class="mw-heading mw-heading2"><h2 id="Einzelnachweise">Einzelnachweise</h2></div>
<ol class="references">
<li id="cite_note-1"><span class="mw-cite-backlink"><a href="#cite_ref-1">↑</a></span> <span class="reference-text">Pamela Kalte u. a., American Men and Women of Science, Thomson Gale 2004</span>
</li>
</ol>
</div><!--htdig_noindex--><div><div class="zim-footer">
Dieser Artikel wurde von <a class="external text" title="Zuletzt bearbeitet am 2019-09-03" href="https://de.wikipedia.org/wiki/?title=Allan_Maxam&oldid=191946099">Wikipedia</a> herausgegeben. Der Text ist unter <a class="external text" href="https://creativecommons.org/licenses/by-sa/4.0/deed.de">Creative Commons Attribution-Share Alike 4.0</a> verfügbar, sofern nicht anders angegeben. Für die Mediendateien können zusätzliche Bedingungen gelten.
</div>
</div><!--/htdig_noindex--></div>
</div>
</main>
</div>
</div>
</div>
<script src="./_webp_/webpHandler.js"></script>
</body></html>